Datlow was the fiction editor of Omni magazine and Omni Online, and edited the ten associated anthologies. She has edited the horror portion of the Year's Best Fantasy and Horror series since 1988 (with Terri Windling editing the fantasy portion through 2003, followed by the team of Gavin Grant and Kelly Link). She has also edited numerous original science fiction, fantasy, and horror anthologies solo, or with Terri Windling. She was editor of the webzine Event Horizon: Science Fiction, Fantasy, and Horror, and was the editor of Sci Fiction. Datlow won the Hugo Award for Best Professional Editor twice, has received two Bram Stoker Awards, seven World Fantasy Awards, three Locus Awards for Best Editor, and has twice led the Science Fiction Chronicle reader's poll.